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Recombinant Human Keratinocye Growth Factor-2 (CRP0881)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Keratinocye Growth Factor-2 CRP0881 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Human Keratinocye Growth Factor-2 produced in E. coli is a 170 amino acid residues consisting of Methionine and the mature human KGF-2 (amino acid residues 40–208) and having a molecular mass of approximately 19.3 kDa.
  • Specificity
  • The biological activity was determined by the does-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors yielding an ED50 <0.5ng/ml.
  • Endotoxin
  • Less than 1EU/μg of rHuKGF-2 as determined by LAL method.
  • Purity
  • >96% by SDS-PAGE and HPLC analyses.
  • Storage
  • This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
  • Reconstitution
  • We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
  • Recombinant Human Keratinocye Growth Factor-2
    PDB rendering based on 1qqk.

BACKGROUND

  • Antigen Description
  • KGF-2(also known as FGF-10) was originally identified from rat embryos by homology-based polymerase chain reaction. Human and mouse KGF-2 were subsequently cloned. The human KGF-2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF-2 shares approximately 92% and 95% amino acid sequence identity with mouse and rat KGF-2, respectively. Among the FGF family members, KGF-2 is most closely related to FGF-7. The expression of KGF-2 transcripts has been shown to be most abundant in the embryo and adult lung. Recombinant KGF-2 preparations have been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. Based on its in vitro biological activities and in vivo expression pattern, KGF-2 has been proposed to play unique roles in the brain, in lung development, wound healing and limb bud formation.
  • Function
  • chemoattractant activity. fibroblast growth factor receptor binding. growth factor activity. heparin binding. protein binding
  • Gene ID
  • 2255
  • Synonyms
  • Fibroblast growth factor 10 precursor; Keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria; fibroblast growth factor 10

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