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Recombinant Mouse Interferon-γ (CRP0897)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Mouse Interferon-γ CRP0897 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Mouse Interferon-γ produced in E. coli is a single non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15.6 kDa.
  • Specificity
  • Fully biologically active when compared to standard. The specific activity as determined in a viral resistance assay is less than 0.1 ng/ml, corresponding to a specific activity of 1.0×107 IU/ mg.
  • Endotoxin
  • Less than 1EU/mg of rmIFN-γ as determined by LAL method.
  • Purity
  • >95% by SDS-PAGE and HPLC analyses.
  • Storage
  • This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
  • Reconstitution
  • We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤20°C. Further dilutions should be made in appropriate buffered solutions.
  • Recombinant Mouse Interferon-γ
    Interferon gamma, Available structures:1eku, 1fg9, 1fyh, 1hig

BACKGROUND

  • Antigen Description
  • Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation.
  • Function
  • cytokine activity; interferon-gamma receptor binding
  • Gene ID
  • 15978
  • Synonyms
  • Ifg; IFN-g; IFN-gamma; Immune Interferon; type II interferon; T cell interferon; MAF; IFNG; IFG; IFI; gamma interferon

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