Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs provides sensitive, specific and accurate SIAT® Naïve T cell proliferation assays to assess immunogenicity, by identifying the epitope sequences that can provoke the proliferation of helper T cells, so that to induce a helper T cell immune response.
Our SIAT® Naïve T cell proliferation assay is an unique, sensitive and accurate approach for immunogenicity assessment, as it utilizes powerful flow cytometry methods, which can accurately determine the percentage of proliferating CD4+ cells and phenotype the T cell responses in details, all with significantly improved overall sensitivity.
Our SIAT® Naïve T cell proliferation assay has been developed to identify the presence or absence of potential T cell epitopes. Thus, it can be applied as a useful tool in preclinical discovery of novel peptides or proteins. It is so sensitive, that can even address the relative immunogenicity between structurally similar molecules. It has been successfully applied to help our clients to distinguish between different candidates, or generate indications for succeeding protein engineering strategies in deimmunization of a potential immunotherapeutic.
Figure 1: Principle of T cell proliferation assay (Thiel et al 2004)
As part of Creative Biolabs SIAT® Immunogenicity System, the T cell proliferation assay can be used for analysis alongside the outcome from cell-free HLA-peptide binding assays for more than 50 class II HLA alleles, for a detailed profile of the helper T cell immune response to one or more drug candidates.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
