Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsAcid-sensing ion channels (ASICs) are a subfamily of epithelial sodium channel (ENaC)-degenerin superfamily of ion channels. Each member of the ASICs family consists of a 500-560 amino acid sequence. The sequence forms a six-pass membrane region, a large extracellular domain, and a cytoplasmic amino-carboxyl terminus that is very important for the channel's intracellular protein interactions and modulations, ion permeability, and gating. ASIC proteins are most detected in the nervous system involved in the regulation of neural plasticity. They function as a sensor of reduced levels of extracellular pH and response to the signal from the neuron. Activated ASIC proteins by extracellular protons can induce their conformational change thereby promoting the influx of sodium ions. Besides, the only variant ASIC1a shows low Ca2+ permeability. Most studies have shown that ASIC proteins play a key role in the progression of many diseases, such as ischemia, multiple sclerosis, and seizures.
There are 5 subtypes (ASIC1-5) in the ASICs family, encoded by ASIC1, ASIC2, ASIC3, ASIC4 and ASIC5 gene respectively. As proton-gated cation channels in the brain, they exert trafficking and synaptic function, involved in the regulation of multiple physical processes, such as pain, taste, and gastrointestinal functions. Most studies have revealed that targeting ASICs family may provide a new therapeutic strategy for neurological diseases. However, the study of ASICs physical functions is still lacking and ASIC4 has no known function yet. The following table shows four members of ASICs family.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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