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- Anti-FOLH1-cytotoxin Compound A ADC-1
Anti-FOLH1-cytotoxin Compound A ADC-1 (CAT#: ADC-W-118)
This ADC product is comprised of an anti-FOLH1 monoclonal antibody conjugated via a linker to cytotoxin Compound A.
- Product Information
- ADC Target
- ADC Antibody
- ADC payload drug
- Antibody clone #
- 2A10
- Name
- FOLH1
- Alternative Names
- FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypep
- Target Entrez Gene ID
- 2346
- Target UniProt ID
- Q04609
- Overview
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
- Overview
- Anti-FOLH1-antibody, clone # 2A10
- Clone #
- 2A10
- Species Reactivity
- Human
- Name
- cytotoxin Compound A
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-1165 | Anti-FOLH1 (Capromab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-432 | Anti-FOLH1-Mc-VC-MMAE ADC-2 | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-1160 | Anti-FOLH1 (Capromab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-158 | Anti-FOLH1-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-1161 | Anti-FOLH1 (Capromab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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