This ADC product is comprised of an anti-GUCY2C monoclonal antibody (clone 5F9)conjugated via a Cleavable peptide linker to a MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
ADC Target
- Alternative Names
- GUCY2C; guanylate cyclase 2C; STAR; DIAR6; GUC2C; MECIL; MUCIL; heat-stable enterotoxin receptor; GC-C; hSTAR; STA receptor; guanylyl cyclase C; intestinal guanylate cyclase; heat stable enterotoxin receptor;
- Target Entrez Gene ID
- 2984
- Overview
- Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.
Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.
ADC Antibody
- Overview
- Human Anti-GUCY2C Antibody, clone # 5F9
ADC Linker
- Name
- Cleavable peptide linker
ADC payload drug
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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