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Anti-TPBG-hydroxyl amino PEG-MMAD ADC-1

Anti-TPBG-hydroxyl amino PEG-MMAD ADC-1 (CAT#: ADC-W-312)

Name: Anti-TPBG-hydroxyl amino PEG-MMAD ADC-1
SKU: ADC-W-312
Rating: 5 (1 reviews)

This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via a hydroxyl amino PEG linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Antibody clone #
A1

Name
TPBG

Alternative Names
M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;

Target Entrez Gene ID
7162

Target UniProt ID
Q13641

Overview
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.

Overview
Humanized Anti-TPBG antibody, clone # A1

Clone #
A1

Species Reactivity
Human

Name
hydroxyl amino PEG linker

Description
Polyethylene glycol (PEG) is a particularly attractive as a linker for conjugation. The specific characteristics of PEG moieties relevant to pharmaceutical applications include: Water solubility; Lack of toxicity; Low immunogenicity; Well defined chain lengths and molecular weights.

Name
MMAD (monomethyl auristatin D)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-167	Anti-TPBG-VC-MMAD ADC-11	VC (valine-citrulline)	MMAD (monomethyl auristatin D)
ADC-W-537	Anti-TPBG-Mc-MMAF ADC	Mc (maleimidocaproyl)	MMAF (Monomethyl auristatin F)
ADC-W-007	Anti-TPBG-VC-MMAE ADC-2	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-163	Anti-TPBG-Mc-MMAD ADC-7	Mc (maleimidocaproyl)	MMAD (monomethyl auristatin D)
ADC-W-164	Anti-TPBG-VC-MMAD ADC-8	VC (valine-citrulline)	MMAD (monomethyl auristatin D)

CAT#	Product Name	Linker	Payload
ADC-W-413	Anti-ERBB2 (Trastuzumab)-hydroxyl amino PEG linker-MMAD (monomethyl auristatin D) ADC	hydroxyl amino PEG linker	MMAD (monomethyl auristatin D)

CAT#	Product Name	Linker	Payload
ADC-W-633	Anti-ERBB2 (trastuzumab)-AcLysGly-MMAD ADC	AcLysGly	MMAD (monomethyl auristatin D)
ADC-W-408	Anti-ERBB2 (Trastuzumab)-MMAD ADC	Non-Cleavable hydroxyl amino PEG linker	MMAD (monomethyl auristatin D)
ADC-W-167	Anti-TPBG-VC-MMAD ADC-11	VC (valine-citrulline)	MMAD (monomethyl auristatin D)
ADC-W-634	Anti-ERBB2 (trastuzumab)-AcLys-β-Ala-MMAD ADC	AcLys-β-ala	MMAD (monomethyl auristatin D)
ADC-W-568	Anti-TACSTD2-VC-MMAD ADC-2	VC (valine-citrulline)	MMAD (monomethyl auristatin D)

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