Gastrointestinal (GI) malignancies are a major global health problem in the world. Although the diagnostic techniques and therapeutic approaches are improved significantly, the survival still remains minor improvement. The development of novel therapeutic agents is critical for the treatment of this cancer. Antibody-drug conjugate (ADC) is a type of novel and effective therapy developed to improve the therapeutic outcome of cytotoxic anti-cancer agents, which allows delivery of the potent drug to the tumor while minimizing exposure of normal tissues. With abundant experience in antibody development, drug production and bio-conjugation, Creative Biolabs offers one-stop-shop development and manufacturing services for your ADCs. Whether you require ADC design, small scale production or commercial scale products, our experts can provide comprehensive services per your request.
Introduction of Gastrointestinal Malignancies
GI malignancies are common and frequently lethal neoplasms, which is a group of cancers that affect the gastrointestinal tract. To date, the specific cause of many types of gastrointestinal malignancies is unknown. Risk factors of the cancer can be divided into different types, including smoking, excessive alcohol consumption, increasing age, diet high in animal fat, diet containing high amounts of salt, chronic pancreatitis and obesity. Symptoms often present abdominal pain, tenderness, or discomfort, rectal bleeding or blood in stool, bloating, loss of appetite, nausea/vomiting, unintentional weight loss and fatigue. Currently, chemotherapy, radiation therapy and surgery are the most common treatment approaches for GI malignancies.
ADC Development for Gastrointestinal Malignancies
ADCs represent a fast-growing new class of anticancer therapeutics, which are designed to selectively carry a potent cytotoxic drug to tumors, while showing limited systemic toxicity to healthy tissues. In recent years, several ADCs are investigated in various stages of clinical development for the treatment of gastrointestinal malignancies to improve patient survival.
Fig.2 The structure of cantuzumab mertansine.
What Can We Do for You?
At Creative Biolabs, targets of ADC development for gastrointestinal malignancies include:
Creative Biolabs is a leading service provider in the field of ADCs design and preparation worldwide. We provide a fully integrated ADC development services against gastrointestinal malignancies. Our services include high affinity antibody development, high-quality drug production and efficient antibody-drug conjugation. Please contact us for more information if you are interested in our services.
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