As a recognized industrial leader in antibody-drug conjugate (ADC) development, Creative biolabs has established a comprehensive analytical platform to evaluate the biochemical properties of a newly designed ADC. We are experienced and committed to provide our clients with top-quality services to elucidate the structural information of your ADC.
Antibody-drug conjugates are a new class of bio-therapeutic complexes that are produced by conjugating highly potent cytotoxic drugs to tumor targeting monoclonal antibodies via a meticulously designed chemical linker. Compared to traditional chemotherapeutic anti-cancer medications, ADCs have achieved targeted drug delivery that increases the total therapeutic efficacy and reduces drug cytotoxicity. The structure of an ADC is a collective combination of its individual components and the chemical conjugation process that leads to ADC generation adds great complexity and heterogeneity to the ADC structure. Combined with their high molecular weights, ADC structural analysis represents a major challenge for analytical scientists.
On a face value, antibody-drug conjugates are more prone for aggregation due to the hydrophobicity of the conjugated payloads. Therefore, the structure of each component (drug, linker and mAb) of an ADC must be redefined using the most appropriate analytical methods. This is not only beneficial for ADC designing, since the structural information of an ADC is a prerequisite for sophisticated downstream evaluations (stability, efficacy…), but also provides a guideline for ADC production.
Here at Creative Biolabs, we analyze the protein fragments/aggregates, charge status, primary structure, secondary/tertiary structures, and post translational modifications (mainly glycosylation) of an ADC to obtain a full picture of its structure:
Circular dichroism measurements of an ADC compared to its mAb. The conjugation process exerted minor structural distortion to the mAb (Pharm Res., 2014)
Creative biolabs has been devoted to help clients with the development of ADCs. We offer high-quality customized analytic services for ADC biochemical evaluation in a timely and cost efficient manner. Please contact us for more information and a detailed quote.
Reference:
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