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- Anti-LYPD3-auristatin ADC
Anti-LYPD3-auristatin ADC (CAT#: ADC-W-561)
This ADC product is comprised of an anti-C44a monoclonal antibody conjugated via a linker to auristatin. The auristatin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, auristatin binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC payload drug
- Name
- LYPD3
- Alternative Names
- LYPD3; LY6/PLAUR Domain Containing 3;GPI-Anchored Metastasis-Associated Protein C4.4A Homolog;Matrigel-Induced Gene C4 Protein;MIG-C4;GPI-Anchored Metastasis-Associated Protein Homolog;Ly6/PLAUR Domain-Containing Protein 3;2310061G07Rik;
- Target Entrez Gene ID
- 27076
- Target UniProt ID
- 095274
- Overview
- This gene is a Protein Coding gene. GO annotations related to this gene include laminin binding. An important paralog of this gene is LYPD5.
- Overview
- Anti-LYPD3 Antibody
- Species Reactivity
- Human
- Name
- Auristatin
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Quick Links
Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-110 | Anti-LYPD3-lysine-toxophore ADC-1 | lysine | toxophore loading |
| ADC-W-111 | Anti-LYPD3-lysine-toxophore ADC-2 | lysine | toxophore loading |
| CAT# | Product Name | Linker | Payload |
| ADC-W-419 | Anti-ERBB2 (Trastuzumab)-auristatin ADC | auristatin | |
| ADC-W-560 | Anti-PTK7-VC-auristatin ADC | VC (valine-citrulline) | Auristatin |
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