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Anti-CCR5 MAb (Clone 1)-iFluor® 555 Succinimidyl Ester (CAT#: WJY0-LS15541)

This product is comprised of an Humanized Anti-CCR5 IgG4 antibody (Clone 1) labeled with iFluor® 555 Succinimidyl Ester. iFluor® 555 Succinimidyl Ester is a Yellow-fluorescent dye and it's excitation/emission is 403/427 nm.

  • TARGET
  • ANTIBODY
  • DYE
  • Name
  • CCR5
  • Alternative Names
  • CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine (C C motif) receptor 5 ; CMKBR5; C-C chemokine receptor type 5; CC CKR 5; CD195; CKR 5; CKR5; IDDM22; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; CCR-5; CKR-5; CCCKR5; CMKBR5; CC-CKR-5; FLJ78003;
  • Overview
  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
  • Overview
  • Humanized Anti-CCR5 IgG4 antibody (Clone 1)
  • Species Reactivity
  • Human
  • Name
  • iFluor® 555 Succinimidyl Ester
  • Color
  • Yellow
  • Excitation⁄Emission (nm)
  • 557/570
  • Detection method
  • Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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