Anti-IL2RA-PBD ADC (ADC-W-555) 
This ADC product is comprised of an anti-IL2RA monoclonal antibody conjugated via a linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PDB binds to DNA, causes DNA damage.
ADC Target
- Name
- IL2RA
- Alternative Names
- IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha;
- Target Entrez Gene ID
- 3559
- Target UniProt ID
- P01589
- Overview
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
ADC Antibody
- Overview
- Anti-IL2RA IgG1 Antibody
- Species Reactivity
- Human
ADC payload drug
- Name
- pyrrolobenzodiazepine (PBD) dimers
- Description
- Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
Online Inquiry
USA
Tel:
Fax:
Email:
Europe
Tel:
Email:
Germany
Tel:
Email:
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
Contact usUSA
Tel:
Fax:
Email:
Europe
Tel:
Email:
Germany
Tel:
Email: