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Anti-IL2RA-PBD ADC (CAT#: ADC-W-555)

This ADC product is comprised of an anti-IL2RA monoclonal antibody conjugated via a linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PDB binds to DNA, causes DNA damage.

  • ADC Target
  • ADC Antibody
  • ADC payload drug
  • Name
  • IL2RA
  • Alternative Names
  • IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha;
  • Target Entrez Gene ID
  • 3559
  • Overview
  • The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
  • Overview
  • Anti-IL2RA IgG1 Antibody
  • Species Reactivity
  • Human
  • Name
  • pyrrolobenzodiazepine (PBD) dimers
  • Description
  • Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
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Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
Protocol

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ADC-W-1370 Anti-IL2RA (Daclizumab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-1372 Anti-IL2RA (Daclizumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-1368 Anti-IL2RA (Basiliximab)-MC-Vc-PAB-SN38 ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-1361 Anti-IL2RA (Inolimomab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
ADC-W-1365 Anti-IL2RA (Basiliximab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
CAT# Product Name Linker Payload
ADC-W-446 Anti-CD70-Mc-VC-PBD ADC-5 mc-VC (maleimidocaproyl-valine-citrulline) pyrrolobenzodiazepine (PBD) dimers
ADC-W-107 Anti-DLL3-PBD dimers ADC-5 pyrrolobenzodiazepine (PBD) dimers
ADC-W-106 Anti-DLL3-PBD dimers ADC-4 pyrrolobenzodiazepine (PBD) dimers
ADC-W-104 Anti-DLL3-PBD dimers ADC-2 pyrrolobenzodiazepine (PBD) dimers
ADC-W-304 Anti-CDH1-PBD dimers ADC pyrrolobenzodiazepine (PBD) dimers

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