- Home
- Products
- Customized ADCs
- CD33
- Anti-CD33-SGD-1910 ADC-2
Anti-CD33-SGD-1910 ADC-2 (CAT#: ADC-W-113)
This ADC product is comprised of an anti-CD33 monoclonal antibody (cloneh2H12d) conjugated via a linker to SGD-1910. The SGD-1910 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, calicheamicin binds to DNA, causes DNA damage, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC payload drug
- Antibody clone #
- h2H12d
- Name
- CD33
- Alternative Names
- CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;
- Target Entrez Gene ID
- 945
- Target UniProt ID
- P20138
- Overview
- CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.
- Overview
- Anti-CD33 antibody, clone # h2H12d
- Clone #
- h2H12d
- Species Reactivity
- Human
- Name
- SGD-1910
- Description
- Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-ITGA4 (Etrolizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1477)
- Anti-MS4A1 (Obinutuzumab)-MC-MMAF ADC (CAT#: ADC-W-2470)
- Anti-E. coli Stx2A (Setoxaximab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2485)
- Anti-IL17RA (Brodalumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1321)
- Anti-TNFRSF17-VC-MMAE ADC-20 (CAT#: ADC-W-281)
- Anti-VEGFA (Ranibizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1939)
- Anti-FN1 (Radretumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1157)
- Anti-CFD (Lampalizumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-983)
- Anti-ANGPT2 MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-666)
- Anti-KDR (Ramucirumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-1519)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-113. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-2541 | Anti-CD33 (Gemtuzumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-815 | Anti-CD33 (Lintuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-464 | Anti-CD33-AcBut-Calicheamicin ADC-5 | AcBut (4-(4-acetylphenoxy)butanoic acid) | Calicheamicin |
| ADC-W-2539 | Anti-CD33 (Gemtuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-2538 | Anti-CD33 (Gemtuzumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
