Anti-CD40LG MAb (Clone 8)-iFluor® 350 Succinimidyl Ester
Anti-CD40LG MAb (Clone 8)-iFluor® 350 Succinimidyl Ester (WJY0-LS1191)
This product is comprised of an Humanized Anti-CD40LG IgG1-kappa (Clone 8) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.
TARGET
Name
CD40LG
Alternative Names
CD40LG; CD40 ligand; HIGM1; IMD3; TNFSF5; tumor necrosis factor (ligand) superfamily; member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tnternalized inside cells; the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase; or similar enzymes; drugs can be released.
Overview
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.