Anti-CEACAM5-Phy-lys-SN-38 ADC (ADC-W-472) 
This ADC product is comprised of an anti-CEACAM5 monoclonal antibody conjugated via a Phy-lys linker to SN-38. The SN-38 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, SN-38 binds to DNA, causes DNA damage.
- Similar to
- IMMU-130 (SN38)
ADC Target
- Name
- CEACAM5
- Alternative Names
- CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100;
- Target Entrez Gene ID
- 1048
- Target UniProt ID
- A0A024R0K5
- Overview
- Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).
ADC Antibody
- Overview
- Humanized Anti-CEACAM5 lgG1 Antibody
- Species Reactivity
- Human
ADC Linker
- Name
- Phy-lys (Phenylalanine-lysine)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
ADC payload drug
- Name
- SN-38 (7-ethyl-10-hydroxycamptothecin)
- Description
- SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1
For Research Use Only. NOT FOR CLINICAL USE.
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