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- Anti-CD70-MC-Vc-PAB-MMAE ADC-7
Anti-CD70-MC-Vc-PAB-MMAE ADC-7 (CAT#: ADC-W-953)
This ADC product is comprised of an anti-CD70 monoclonal antibody conjugated via a MC-Vc linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- CD70
- Alternative Names
- CD70; CD70 molecule; CD27LG, TNFSF7, tumor necrosis factor (ligand) superfamily, member 7; CD70 antigen; CD27L; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) sup
- Target Entrez Gene ID
- 970
- Target UniProt ID
- P32970
- Overview
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferat
- Overview
- Humanized Anti-CD70 IgG1-kappa antibody
- Generic name
- Anti-CD70 antiody
- Host animal
- Mouse
- Species Reactivity
- Human
- Name
- MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAE
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-IL9 (Enokizumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1452)
- Anti-NOTCH2 (Tarextumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2220)
- Anti-TNFRSF17-VC-MMAE ADC-23 (CAT#: ADC-W-284)
- Anti-TAG-72 (Satumomab Pendetide)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2160)
- Anti-FCER2 (Lumiliximab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1140)
- Anti-EGFR-S-3AA-MDC ADC-2 (CAT#: ADC-W-126)
- Anti-CD4 (Tregalizumab)-SPDB-DM4 ADC (CAT#: ADC-W-873)
- Anti-CD70-bac-MMAF ADC-3 (CAT#: ADC-W-361)
- Anti-MUC16 (Abagovomab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1638)
- Anti-CD5 (Zolimomab aritox)-MC-MMAF ADC (CAT#: ADC-W-928)
Published Data
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Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-955 | Anti-CD70-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC-7 | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-587 | Anti-CD70-Mc-VC-PABC-MMAE ADC-5 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
| ADC-W-446 | Anti-CD70-Mc-VC-PBD ADC-5 | mc-VC (maleimidocaproyl-valine-citrulline) | pyrrolobenzodiazepine (PBD) dimers |
| ADC-W-452 | Anti-CD70-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-376 | Anti-CD70-β-glucuronide-doxorubicin ADC-5 | β-glucuronide linker | doxorubicin |
| CAT# | Product Name | Linker | Payload |
| ADC-W-2593 | Anti-EGFR (Cetuximab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2587 | Anti-EGFR (Zalutumumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2624 | Anti-NCAM1 (Lorvotuzumab )-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2592 | Anti-EGFR (Cetuximab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2607 | Anti-ITGB3 (Tadocizumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| CAT# | Product Name | Linker | Payload |
| ADC-W-2557 | Anti-CD79B (Polatuzumab )-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2574 | Anti-SLC34A2 (Lifastuzumab )-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2568 | Anti-MUC16 (Sofituzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2592 | Anti-EGFR (Cetuximab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2551 | Anti-CD74-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
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