Anti-CD70-VC-rachelmycin ADC (ADC-W-367)

This ADC product is comprised of an anti-CD70 monoclonal antibody conjugated via a VC linker to a rachelmycin. The rachelmycin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, rachelmycin binds to DNA, causes DNA damage.
  • Antibody clone #
  • h1F6

 ADC Target

  • Name
  • CD70
  • Alternative Names
  • CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
  • Target Entrez Gene ID
  • 970
  • Overview
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

 ADC Antibody

  • Overview
  • Humanized Anti-CD70 lgG1 Antibody, clone # h1f6
  • Clone #
  • h1F6
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • CC-1065 (rachelmycin)
  • Description
  • CC-1065 is a kind of natural DNA alkylators and can be used as anti-tumor therapic agent because it can bind tightly to the minor groove of DNA and then react covalently with adenine bases.

For lab research use only, not for any in vivo human use.


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