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Anti-CD70-VC-MED-2460-ADC (CAT#: ADC-W-471)

This ADC product is comprised of an anti-CD70 monoclonal antibody conjugated via a VC linker to MED. The MED is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to DNA, causes DNA damage.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Similar to
  • MDX-1203
  • Name
  • CD70
  • Alternative Names
  • CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
  • Target Entrez Gene ID
  • 970
  • Overview
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
  • Overview
  • Human Anti-CD70 lgG1 Antibody
  • Species Reactivity
  • Human
  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MED-2460
  • Description
  • Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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Development of Monoclonal Antibodies
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CAMouse™-Fully Human Antibody Generation Platform
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ADC-W-446 Anti-CD70-Mc-VC-PBD ADC-5 mc-VC (maleimidocaproyl-valine-citrulline) pyrrolobenzodiazepine (PBD) dimers
ADC-W-952 Anti-CD70-MC-MMAF ADC-7 MC (maleimidocaproyl) MMAF
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ADC-W-587 Anti-CD70-Mc-VC-PABC-MMAE ADC-5 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-487 Anti-CD70-MCC-DM1 ADC MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
CAT# Product Name Linker Payload
ADC-AA-056 Anti-MIgG-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
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ADC-W-536 Anti-EDNRB (endothelin B)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)

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