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Anti-CD74-hindered disulfide-Doxorubicin ADC (CAT#: ADC-W-378)

This ADC product is comprised of an anti-CD74 monoclonal antibody conjugated via a hindered disulfide linker to a Doxorubicin. The doxorubicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, doxorubicin binds to DNA, causes DNA damage.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • CD74
  • Alternative Names
  • CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of clas
  • Target Entrez Gene ID
  • 972
  • Overview
  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Overview
  • Humanized Anti-CD74 Antibody
  • Species Reactivity
  • Human
  • Name
  • hindered disulfide
  • Name
  • doxorubicin
  • Description
  • Doxorubicin is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
Reviews
Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
Protocol

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Other Products

Same Target Same Payload
CAT# Product Name Linker Payload
ADC-W-039 Anti-CD74-Mc-MMAF ADC-1 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-2551 Anti-CD74-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
ADC-W-2548 Anti-CD74-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-2553 Anti-CD74-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-036 Anti-CD74-VC-MMAE ADC-1 VC (valine-citrulline) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
ADC-W-504 Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) Doxorubicin
ADC-W-581 Anti-EpCAM-hydrazone-Doxorubicin ADC-2 acid-cleavable hydrazone linker doxorubicin
ADC-W-502 Anti-EGFR-SMCC-Dox ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) Doxorubicin
ADC-W-503 Anti-EGFR-EDC/NHS-Dox ADC EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide) Doxorubicin
ADC-W-600 Anti-EGFR-doxorubicin ADC polyethylene glycol linker doxorubicin

For Research Use Only. NOT FOR CLINICAL USE.

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