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- Anti-CDH1 MAb (Clone 1)-iFluor® 440 Succinimidyl Ester
Anti-CDH1 MAb (Clone 1)-iFluor® 440 Succinimidyl Ester (CAT#: WJY0-LS5003)
This product is comprised of an Anti-CDH1 Antibody (Clone 1) labeled with iFluor® 440 Succinimidyl Ester. iFluor® 440 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- CDH1
- Alternative Names
- CDH1; Arc-1; CD324; CDHE; ECAD; LCAM; UVO; cadherin 1; BCDS1
- Overview
- Cadherin-1 (not to be confused with the APC C activating protein CDH1), also known as CAM 120 80 or E-cadherin or uvomorulin, is a human protein encoded by the CDH1 gene. CDH1 has also been designated as CD324 (Differentiation Cluster 324). It is a tumor suppressor gene.
E-cadherin (epithelium) is the most thoroughly studied member of the cadherin family. It consists of 5 cadherin repeats in the extracellular domain (EC1 ~ EC5), a transmembrane domain and an intracellular domain that binds to p120-catenin and β-catenin. The intracellular domain contains a highly phosphorylated region, which is essential for β-catenin binding and therefore for E-cadherin function. [Citation needed] β-catenin can also be combined with α-catenin. Alpha-catenin is involved in the regulation of actin-containing cytoskeletal filaments. In epithelial cells, E-cadherin-containing intercellular junctions are usually adjacent to actin-containing filaments in the cytoskeleton.
- Overview
- Anti-CDH1 Antibody (Clone 1)
- Species Reactivity
- Human
- Name
- iFluor® 440 Succinimidyl Ester
- Color
- Green
- Excitation⁄Emission (nm)
- 434/480
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-304 | Anti-CDH1-PBD dimers ADC | pyrrolobenzodiazepine (PBD) dimers |
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