Anti-CFD MAb (Clone 4)-iFluor® 555 Succinimidyl Ester (WJY0-LS16606)

This product is comprised of an Humanized Anti-CFD IgG1-kappa (Clone 4) labeled with iFluor® 555 Succinimidyl Ester. iFluor® 555 Succinimidyl Ester is a Yellow-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
CFD

Alternative Names
CFD; complement factor D (adipsin); D component of complement (adipsin) ; DF; PFD; properdin factor D; complement factor D; ADN; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin); DF; PFD; ADIPSIN;

Overview
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.

ANTIBODY

Overview
Humanized Anti-CFD IgG1-kappa (Clone 4)

Species Reactivity
Human

DYE

Name
iFluor® 555 Succinimidyl Ester

Color
Yellow

Excitation⁄Emission (nm)
557/570

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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