This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ADC Antibody
Overview
Humanized Anti-CXCR4 Antibody
Species Reactivity
Human
ADC Linker
Name
disulfide-cleavable linkers
ADC payload drug
Name
dasatinib
Description
Dasatinib, also known as BMS-354825, is a cancer drug. It is an oral Bcr-Abl tyrosine kinase inhibitorand Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).