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- Anti-CXCR4-PEG-S-4FB-dasatinib ADC
Anti-CXCR4-PEG-S-4FB-dasatinib ADC (CAT#: ADC-W-519)
This ADC product is comprised of an anti-CXCR4 monoclonal antibody conjugated via a PEG-S-4FB linker to dasatinib.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- CXCR4
- Alternative Names
- CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y rece
- Target Entrez Gene ID
- 7852
- Target UniProt ID
- P61073
- Overview
- This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
- Overview
- Humanized Anti-CXCR4 Antibody
- Species Reactivity
- Human
- Name
- PEG-S-4FB linker
- Name
- dasatinib
- Description
- Dasatinib, also known as BMS-354825, is a cancer drug. It is an oral Bcr-Abl tyrosine kinase inhibitorand Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-520 | Anti-CXCR4-dasatinib ADC | disulfide-cleavable linkers | dasatinib |
| ADC-W-1924 | Anti-CXCR4 (Ulocuplumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1925 | Anti-CXCR4 (Ulocuplumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1923 | Anti-CXCR4 (Ulocuplumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1922 | Anti-CXCR4 (Ulocuplumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-520 | Anti-CXCR4-dasatinib ADC | disulfide-cleavable linkers | dasatinib |
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