- Home
- Products
- Customized ADCs
- DLL3
- Anti-DLL3-PBD ADC
Anti-DLL3-PBD ADC (CAT#: ADC-W-558)
This ADC product is comprised of an anti-DLL3 monoclonal antibody conjugated via a linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PDB binds to DNA, causes DNA damage.
- ADC Target
- ADC Antibody
- ADC payload drug
- Name
- DLL3
- Alternative Names
- DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3;
- Target Entrez Gene ID
- 10683
- Target UniProt ID
- Q9NYJ7
- Overview
- This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
- Overview
- Anti-DLL3 Antibody
- Species Reactivity
- Human
- Name
- pyrrolobenzodiazepine (PBD) dimers
- Description
- Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-ERBB2 (Margetuximab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1110)
- Anti-CD40LG (Toralizumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-924)
- Anti-CCR5 (PRO 140)-SMCC-DM1 ADC (CAT#: ADC-W-764)
- Anti-HGF (Ficlatuzumab)-SPDB-DM4 ADC (CAT#: ADC-W-1197)
- Anti-MS4A1 (Tositumomab)-SPDB-DM4 ADC (CAT#: ADC-W-1581)
- Anti-TACSTD2-AcLys-VC-PABC-0101 ADC-1 (CAT#: ADC-W-293)
- Anti-IL17RA (Brodalumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1320)
- Anti-FcRL5-SPDB-DM4 ADC-3 (CAT#: ADC-W-401)
- Anti-CD74-Mc-MMAF ADC-1 (CAT#: ADC-W-039)
- Anti-PVRL4-MC-MMAF ADC (CAT#: ADC-W-2398)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-558. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-107 | Anti-DLL3-PBD dimers ADC-5 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-102 | Anti-DLL3-PBD dimers ADC-1 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-105 | Anti-DLL3-PBD dimers ADC-3 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-498 | Anti-DLL3-D6.5 ADC | D6.5 | |
| ADC-W-104 | Anti-DLL3-PBD dimers ADC-2 | pyrrolobenzodiazepine (PBD) dimers |
| CAT# | Product Name | Linker | Payload |
| ADC-W-102 | Anti-DLL3-PBD dimers ADC-1 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-446 | Anti-CD70-Mc-VC-PBD ADC-5 | mc-VC (maleimidocaproyl-valine-citrulline) | pyrrolobenzodiazepine (PBD) dimers |
| ADC-W-304 | Anti-CDH1-PBD dimers ADC | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-105 | Anti-DLL3-PBD dimers ADC-3 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-104 | Anti-DLL3-PBD dimers ADC-2 | pyrrolobenzodiazepine (PBD) dimers |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
