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Anti-DLL3-PBD ADC (ADC-W-558)

This ADC product is comprised of an anti-DLL3 monoclonal antibody conjugated via a linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PDB binds to DNA, causes DNA damage.

 ADC Target

  • Name
  • DLL3
  • Alternative Names
  • DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3;
  • Target Entrez Gene ID
  • 10683
  • Overview
  • This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

 ADC Antibody

  • Overview
  • Anti-DLL3 Antibody
  • Species Reactivity
  • Human

 ADC payload drug

  • Name
  • pyrrolobenzodiazepine (PBD) dimers
  • Description
  • Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

For Research Use Only. NOT FOR CLINICAL USE.

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