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- Anti-ERBB3 MAb (Clone 9)-iFluor® 350 Succinimidyl Ester
Anti-ERBB3 MAb (Clone 9)-iFluor® 350 Succinimidyl Ester (CAT#: WJY0-LS1257)
This product is comprised of an Chimeric Humanized Anti-ERBB3 IgG1-kappa-[scFv-heavy-lambda]2 (Clone 9) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- ERBB3
- Alternative Names
- ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2; lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
- Overview
- This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
- Overview
- Chimeric Humanized Anti-ERBB3 IgG1-kappa-[scFv-heavy-lambda]2 (Clone 9)
- Species Reactivity
- Human
- Name
- iFluor® 350 Succinimidyl Ester
- Color
- Blue
- Excitation⁄Emission (nm)
- 345/450
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| ADC-W-2368 | Anti-ERBB3 (Duligotuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-2242 | Anti-ERBB3 (Duligotumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1129 | Anti-ERBB3 (Seribantumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-1128 | Anti-ERBB3 (Seribantumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2243 | Anti-ERBB3 (Duligotumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
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