Anti-FOLR1-DGN462 ADC (ADC-W-562)

This ADC product is comprised of an anti-FOLR1 monoclonal antibody conjugated via a linker to DGN462. The DGN462 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.

ADC Target

Name
FOLR1

Alternative Names
FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;

Target Entrez Gene ID
2348

Target UniProt ID
A0A024R5H1

Overview
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

ADC Antibody

Overview
Anti-FOLR1 Antibody

ADC Linker

Name
maleimide containing linkers

ADC payload drug

Name
DGN462

Description
DGN462,the mono-imine IGN, highly potent cytotoxic DNA alkylateing agent.DGN462 formed covalent DNA adducts through alkylation of the C2-amino group of guanine.

For Research Use Only. NOT FOR CLINICAL USE.

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