Anti-GD2 MAb (Clone 4)-iFluor® 450 Succinimidyl Ester (WJY0-LS7728)

This product is comprised of an Chimeric Anti-GD2 IgG1-kappa (Clone 4) labeled with iFluor® 450 Succinimidyl Ester. iFluor® 450 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
GD2

Alternative Names
Ganglioside GD2; GD2

Overview
GD2 is a disialic ganglioside expressed in tumors of neuroectodermal origin (including human neuroblastoma and melanoma), and its expression in normal tissues (mainly human cerebellum and peripheral nerves) is highly restricted.

The relative tumor-specific expression of GD2 makes it a suitable target for immunotherapy using monoclonal antibodies or artificial T cell receptors. An example of such an antibody is hu14.18K322A, a monoclonal antibody. The anti-GD2 antibody is currently in phase II clinical trials for the treatment of previously untreated high-risk neuroblastoma and combined chemotherapy prior to stem cell transplantation and radiation therapy. A previous phase I clinical trial designed to reduce toxicity in patients with refractory or recurrent neuroblastoma found a safe dose and determined that common toxicity, especially pain, can be well controlled.

ANTIBODY

Overview
Chimeric Anti-GD2 IgG1-kappa (Clone 4)

Species Reactivity
Human

DYE

Name
iFluor® 450 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
451/502

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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