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- Anti-ITIH4-Mc-MMAF ADC
Anti-ITIH4-Mc-MMAF ADC (CAT#: ADC-W-229)
This ADC product is comprised of an anti-gp120 monoclonal antibody conjugated via a Mc linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- ITIH4
- Alternative Names
- H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4
- Target Entrez Gene ID
- 3700
- Target UniProt ID
- Q14624
- Overview
- The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
- Overview
- Anti-ITIH4 IgG1 Antibody
- Species Reactivity
- Mouse
- Name
- Mc (maleimidocaproyl)
- Description
- Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-226 | Anti-ITIH4-SPP-DM1 ADC | SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-227 | Anti-ITIH4-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-228 | Anti-ITIH4-Mc-VC-PABC-MMAE ADC | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-452 | Anti-CD70-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-2612 | Anti-MS4A1 (Rituximab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-478 | Anti-ENPP3-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-115 | Anti-CD33-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-515 | Anti-EGFR-Mc-MMAF ADC-5 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-002 | anti-HIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-020 | anti-MIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-053 | Protein A-MMAF ADC | MMAF (Monomethyl auristatin F) | |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-010 | anti-HIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
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