What is the purpose of the Anti-HIgG(Fc)-C-DX8951 ADC?

The Anti-HIgG(Fc)-C-DX8951 ADC is designed to conjugate a secondary antibody specific for mouse IgG Fc to a cytotoxic small molecule, DMDM, via a cleavable linker, facilitating pre-screening of mouse monoclonal antibodies as ADC candidates.

How does the cleavable linker in Anti-HIgG(Fc)-C-DX8951 ADC function?

The cleavable linker ensures that DMDM is released once the ADC is internalized by target cells, allowing the cytotoxic drug to bind DNA and induce damage.

Is Anti-HIgG(Fc)-C-DX8951 ADC suitable for in vivo studies?

Yes, but optimal dosing and potential side effects should be carefully evaluated in preliminary studies.

What types of primary antibodies can be used with this ADC?

Any mouse monoclonal antibodies that are candidates for ADC development can be pre-screened using this product.

What are the safety considerations when handling this ADC?

As it contains a cytotoxic component, proper safety protocols, including the use of personal protective equipment (PPE), should be followed.

How can I optimize the use of Anti-HIgG(Fc)-C-DX8951 ADC in my experiments?

Start with recommended dilutions and perform titration experiments to determine the optimal concentration and conditions for your specific application.

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Anti-HIgG(Fc)-C-DX8951 ADC

Anti-HIgG(Fc)-C-DX8951 ADC (CAT#: ADC-AA-060)

This ADC product is comprised of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to exatecan mesylate (DX8951). DX8951 is a topoisomerase I inhibitor.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Alternative Names
Immunoglobulin G; IgG; Fc

Overview
The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.

Overview
Anti-human IgG Fc specific polyclonal IgG antibody

Species Reactivity
Human

Name
Cleavable linkers

Description
Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulﬁde-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.

Name
DX8951

Description
DX8951, a novel water-soluble camptothecin analog, is a DNA topoisomerase I inhibitor.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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Literature

Protocol

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Customer Reviews FAQ

Excellent

Highly effective ADC! The specificity of Anti-HIgG(Fc)-C-DX8951 was spot on for our assays. Very satisfied with the quality and performance.

Excellent

Excellent conjugation and linker stability. The product showed great results in our topoisomerase inhibition studies. Prompt delivery as well.

Excellent

Consistent performance

Top-notch ADC from Creative Biolabs. The glycosylation of Fc was perfect for our receptor-mediated assays.

Excellent

Recommended

Anti-HIgG(Fc)-C-DX8951 ADC worked exceptionally well in our cytotoxicity assays. High specificity and negligible non-specific binding.

Excellent

Impressive antibody-drug conjugate! The cleavable linker and DX8951 provided optimal results in our lab tests. Quick and reliable shipping.

Excellent

Superior quality ADC! The anti-human IgG Fc specificity and topoisomerase inhibition properties met all our expectations. Great value for the price.

Q: 1: What is the purpose of the Anti-HIgG(Fc)-C-DX8951 ADC?
A: The Anti-HIgG(Fc)-C-DX8951 ADC is designed to conjugate a secondary antibody specific for mouse IgG Fc to a cytotoxic small molecule, DMDM, via a cleavable linker, facilitating pre-screening of mouse monoclonal antibodies as ADC candidates.
Q: 2: How does the cleavable linker in Anti-HIgG(Fc)-C-DX8951 ADC function?
A: The cleavable linker ensures that DMDM is released once the ADC is internalized by target cells, allowing the cytotoxic drug to bind DNA and induce damage.
Q: 3: Is Anti-HIgG(Fc)-C-DX8951 ADC suitable for in vivo studies?
A: Yes, but optimal dosing and potential side effects should be carefully evaluated in preliminary studies.
Q: 4: What types of primary antibodies can be used with this ADC?
A: Any mouse monoclonal antibodies that are candidates for ADC development can be pre-screened using this product.
Q: 5: What are the safety considerations when handling this ADC?
A: As it contains a cytotoxic component, proper safety protocols, including the use of personal protective equipment (PPE), should be followed.
Q: 6: How can I optimize the use of Anti-HIgG(Fc)-C-DX8951 ADC in my experiments?
A: Start with recommended dilutions and perform titration experiments to determine the optimal concentration and conditions for your specific application.

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ADC-AA-031	anti-MIgG(Fc)Fab-N-DM1 ADC	Noncleavable linkers	DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-AA-052	Protein A-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-AA-066	Anti-Rat IgG(H+L)-C-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
ADC-AA-020	anti-MIgG(Fc)-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
WJY-0423-LS108	Protein G-Amanitin ADC	Cleavable linkers	Amanitin
ADC-AA-002	anti-HIgG(Fc)-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-010	anti-HIgG(Fc)Fab-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)

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