Anti-IL13 MAb (Clone 10)-iFluor® 350 Succinimidyl Ester (WJY0-LS1309)

This product is comprised of an Chimeric Humanized Anti-IL13 [VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer) (Clone 10) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.

TARGET

Name
IL13

Alternative Names
Interleukin-13; P600; IL-13

Overview
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

ANTIBODY

Overview
Chimeric Humanized Anti-IL13 [VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer) (Clone 10)

Species Reactivity
Human

DYE

Name
iFluor® 350 Succinimidyl Ester

Color
Blue

Excitation⁄Emission (nm)
345/450

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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