Anti-IL13 MAb (Clone 4)-iFluor® 350 Succinimidyl Ester
Anti-IL13 MAb (Clone 4)-iFluor® 350 Succinimidyl Ester (WJY0-LS1303)
This product is comprised of an Humanized Anti-IL13 Fab-G1-kappa (Clone 4) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.
TARGET
Name
IL13
Alternative Names
Interleukin-13; P600; IL-13
Overview
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.