Anti-IL17A MAb (Clone 13)-iFluor® 430 Succinimidyl Ester
Anti-IL17A MAb (Clone 13)-iFluor® 430 Succinimidyl Ester (WJY0-LS4396)
This product is comprised of an Humanized Anti-IL17A IgG4-kappa (Clone 13) labeled with iFluor® 430 Succinimidyl Ester. iFluor® 430 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
Name
IL17A
Alternative Names
IL17a
Overview
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.