Anti-IL17A MAb (Clone 4)-iFluor® 488 Succinimidyl Ester
Anti-IL17A MAb (Clone 4)-iFluor® 488 Succinimidyl Ester (WJY0-LS10539)
This product is comprised of an Chimeric Humanized Anti-IL17A IgG1-kappa (Clone 4) labeled with iFluor® 488 Succinimidyl Ester. iFluor® 488 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
Name
IL17A
Alternative Names
IL17a
Overview
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.