Anti-IL17A MAb (Clone 8)-iFluor® 514 Succinimidyl Ester
Anti-IL17A MAb (Clone 8)-iFluor® 514 Succinimidyl Ester (WJY0-LS12081)
This product is comprised of an Human Anti-IL17A IgG1-kappa[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer (Clone 8) labeled with iFluor® 514 Succinimidyl Ester. iFluor® 514 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
Name
IL17A
Alternative Names
IL17a
Overview
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
ANTIBODY
Overview
Human Anti-IL17A IgG1-kappa[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer (Clone 8)