Anti-IL22 MAb (Clone 2)-iFluor® 546 Succinimidyl Ester (WJY0-LS15169)

This product is comprised of an Human Anti-IL22 IgG1-kappa (Clone 2) labeled with iFluor® 546 Succinimidyl Ester. iFluor® 546 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
IL22

Alternative Names
Interleukin-22; zcyto18; IL-TIF; IL-22; IL-21; IL-D110; TIFa; ILTIF; TIFIL-23; IL-10-related T-cell-derived-inducible factor; Cytokine Zcyto18

Overview
Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).

ANTIBODY

Overview
Human Anti-IL22 IgG1-kappa (Clone 2)

Species Reactivity
Human

DYE

Name
iFluor® 546 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
541/557

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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