This product is comprised of an Human Anti-IL23A IgG1-lambda (Clone 4) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.
TARGET
- Alternative Names
- IL23A; IL-23; IL-23A; IL23P19; P19; SGRF; Interleukin 23; interleukin 23 subunit alpha
- Overview
- IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration into tumours. IL-23 mediates its effects on both innate and adaptive arms of the immune system that express the IL-23 receptor. Th17 cells represent the most prominent T cell subset that responds to IL-23, although IL-23 has been implicated in inhibiting the development of regulatory T cell development in the intestine. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of other proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
ANTIBODY
- Overview
- Human Anti-IL23A IgG1-lambda (Clone 4)
DYE
- Name
- iFluor® 350 Succinimidyl Ester
- Excitation⁄Emission (nm)
- 345/450
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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