This product is comprised of an Chimeric Humanized Anti-IL4 [VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer (Clone 4) labeled with iFluor® 440 Succinimidyl Ester. iFluor® 440 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
- Alternative Names
- Interleukin 4
- Overview
- The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
ANTIBODY
- Overview
- Chimeric Humanized Anti-IL4 [VH-VH'-H-Gamma4_VL-VL'-C-kappa]-dimer (Clone 4)
DYE
- Name
- iFluor® 440 Succinimidyl Ester
- Excitation⁄Emission (nm)
- 434/480
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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