This product is comprised of an Human Anti-IL4R IgG1-kappa (Clone 3) labeled with iFluor® 450 Succinimidyl Ester. iFluor® 450 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
- Alternative Names
- CD124; IL-4RA; IL-4R subunit alpha; Soluble IL-4R-alpha; IL-4 receptor subunit alpha; IL4RA; CD antigen CD124; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; IL-4R-alpha; IL-4-binding protein; IL4-BP; Interleukin-4 receptor subunit alpha
- Overview
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
ANTIBODY
- Overview
- Human Anti-IL4R IgG1-kappa (Clone 3)
DYE
- Name
- iFluor® 450 Succinimidyl Ester
- Excitation⁄Emission (nm)
- 451/502
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
Related Products