Anti-IL5RA MAb (Clone 1)-iFluor® 440 Succinimidyl Ester (WJY0-LS5250)

This product is comprised of an Humanized Anti-IL5RA IgG1-kappa antibody (Clone 1) labeled with iFluor® 440 Succinimidyl Ester. iFluor® 440 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
IL5RA

Alternative Names
CD125; CDw125; IL-5 receptor subunit alpha; IL5R; Interleukin-5 receptor subunit alpha; CD antigen CD125; HSIL5R3; IL-5R-alpha; IL-5R subunit alpha; IL-5RA

Overview
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

ANTIBODY

Overview
Humanized Anti-IL5RA IgG1-kappa antibody (Clone 1)

Species Reactivity
Human

DYE

Name
iFluor® 440 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
434/480

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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