Anti-IL6 MAb (Clone 4)-iFluor® 555 Succinimidyl Ester (WJY0-LS16020)

This product is comprised of an Human Anti-IL6 IgG1-kappa antibody (Clone 4) labeled with iFluor® 555 Succinimidyl Ester. iFluor® 555 Succinimidyl Ester is a Yellow-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
IL6

Alternative Names
IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Overview
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory muscle factor. In humans, it is encoded by the IL6 gene.

In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Many vascular smooth muscle cells also produce IL-6 as a proinflammatory cytokine. The role of IL-6 as an anti-inflammatory actin is mediated by its inhibitory effect on TNF-α and IL-1 and the activation of IL-1ra and IL-10.

Early evidence suggests that in the context of a broader coronavirus pandemic, IL-6 can be used as an inflammatory marker of severe COVID-19 infection with a poor prognosis.

ANTIBODY

Overview
Human Anti-IL6 IgG1-kappa antibody (Clone 4)

Species Reactivity
Human

DYE

Name
iFluor® 555 Succinimidyl Ester

Color
Yellow

Excitation⁄Emission (nm)
557/570

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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