Anti-IL6R MAb (Clone 3)-iFluor® 546 Succinimidyl Ester
Anti-IL6R MAb (Clone 3)-iFluor® 546 Succinimidyl Ester (WJY0-LS15200)
This product is comprised of an Human Anti-IL6R IgG1-kappa (Clone 3) labeled with iFluor® 546 Succinimidyl Ester. iFluor® 546 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
Name
IL6R
Alternative Names
IL6R
Overview
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta); a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases; such as multiple myeloma; autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.