Anti-KDR MAb (Clone 7)-iFluor® 546 Succinimidyl Ester (WJY0-LS14858)

This product is comprised of an Human Anti-KDR IgG1-kappa (Clone 7) labeled with iFluor® 546 Succinimidyl Ester. iFluor® 546 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
KDR

Alternative Names
FLK1; VEGFR; CD antigen CD309; FLK-1; Fetal liver kinase 1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; CD309; Kinase insert domain receptor; EC 2.7.10.1; Protein-tyrosine kinase receptor flk-1; KDR

Overview
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

ANTIBODY

Overview
Human Anti-KDR IgG1-kappa (Clone 7)

Species Reactivity
Human

DYE

Name
iFluor® 546 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
541/557

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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