Anti-NOTCH3 MAb (Clone 2)-iFluor® 440 Succinimidyl Ester (WJY0-LS5677)

This product is comprised of an Human Anti-NOTCH3 IgG2-kappa (Clone 2) labeled with iFluor® 440 Succinimidyl Ester. iFluor® 440 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
NOTCH3

Alternative Names
Notch 3; Neurogenic Locus Notch Homolog Protein 3; Notch (Drosophila) Homolog 3; Notch Homolog 3 (Drosophila); Notch Homolog 3; CADASIL1;

Overview
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

ANTIBODY

Overview
Human Anti-NOTCH3 IgG2-kappa (Clone 2)

Species Reactivity
Human

DYE

Name
iFluor® 440 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
434/480

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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