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- Anti-PDGFRA MAb (Clone 2)-iFluor® 405 Succinimidyl Ester
Anti-PDGFRA MAb (Clone 2)-iFluor® 405 Succinimidyl Ester (CAT#: WJY0-LS2222)
This product is comprised of an Human Anti-PDGFRA IgG2-kappa antibody (Clone 2) labeled with iFluor® 405 Succinimidyl Ester. iFluor® 405 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- PDGFRA
- Alternative Names
- alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; CD140a; EC 2.7.10; EC 2.7.10.1; MGC74795; PDGF R alpha; PDGFR alpha; PDGFR2; PDGFRA; PDGFRA BCR fusion; PDGF-R-alpha; platelet-derived growth factor receptor; alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA
- Overview
- PDGFRA, platelet-derived growth factor receptor A, also known as PDGFRα, platelet-derived growth factor receptor α, or CD140a, differentiation cluster 140a, is a receptor located on the surface of various cell types. The receptor binds to certain isoforms of platelet-derived growth factor (PDGF), thereby becoming active in cell signaling pathways that stimulate reactions that cause reactions such as cell growth and differentiation. This receptor is essential for the development of certain tissues and organs during embryogenesis and for maintaining them throughout life, especially blood tissues. The mutation in the gene encoding PDGFRA, the PDGFRA gene, is associated with a series of clinically significant tumors.
- Overview
- Human Anti-PDGFRA IgG2-kappa antibody (Clone 2)
- Species Reactivity
- Human
- Name
- iFluor® 405 Succinimidyl Ester
- Color
- Blue
- Excitation⁄Emission (nm)
- 403/427
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-1712 | Anti-PDGFR (Tovetumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-1709 | Anti-PDGFR (Olaratumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1713 | Anti-PDGFR (Tovetumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1707 | Anti-PDGFR (Olaratumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1710 | Anti-PDGFR (Olaratumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
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