Anti-Rat IgG(H+L)-C-PBD ADC (ADC-AA-066)

This ADC product is comprised of an anti-rabbit IgG(H+L) specific polyclonal antibody conjugated via a cleavable linker to PBD (pyrrolobenzodiazepine).The antibody portion is a secondary antibody. PBD is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA.

ADC Target

Overview
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system, which is a protein complex composed of four peptide chains-two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers. IgG is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses.

ADC Antibody

Overview
Anti-rabbit IgG(H+L) specific polyclonal antibody

Species Reactivity
Rabbit

ADC Linker

Name
Cleavable linkers

Description
Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracel

ADC payload drug

Name
PBD (pyrrolobenzodiazepine)

Description
Derived from various actinomycetes that show strong anti-tumor or antibiotic activities. PBDs are sequence-dependent DNA alkylating compounds and are proven to be more powerful than systemic chemotherapeutic drugs. As DNA minor groove binding agents, PBDs selectively cross-link specific DNA segments, hindering cell division and eventually lead to cell death.

For Research Use Only. NOT FOR CLINICAL USE.

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