What is the composition of the Anti-Rat IgG(H+L)-C-PBD ADC?

The Anti-Rat IgG(H+L)-C-PBD ADC is composed of an anti-rabbit IgG(H+L) specific polyclonal antibody conjugated via a cleavable linker to pyrrolobenzodiazepine (PBD). The antibody serves as a secondary antibody, and PBD is a cytotoxic small molecule that binds to the DNA minor groove, cross-linking specific sites to inhibit DNA replication.

How does PBD function in the Anti-Rat IgG(H+L)-C-PBD ADC?

PBD, or pyrrolobenzodiazepine, is the cytotoxic component in this ADC. It functions by binding to the minor groove of DNA and cross-linking specific sites, thereby preventing the replication of DNA and leading to cell death. This mechanism is critical for targeting and eliminating cells that are bound by the antibody.

What is the role of the anti-rabbit IgG(H+L) polyclonal antibody in this ADC?

The anti-rabbit IgG(H+L) polyclonal antibody in this ADC specifically targets rabbit IgG antibodies. It serves as a secondary antibody, enabling the delivery of the cytotoxic PBD to cells that are bound by the primary antibody. This specificity ensures that PBD is directed only to the targeted cells, enhancing the efficacy of the ADC.

What support services does Creative Biolabs offer for using this ADC product?

Creative Biolabs offers comprehensive support services, including technical consultation on experimental design, optimization of ADC concentration and incubation times, and troubleshooting. They also provide custom conjugation services if specific modifications to the ADC are required for particular research applications.

Can the Anti-Rat IgG(H+L)-C-PBD ADC be customized for specific research needs?

Yes, Creative Biolabs offers customization services for this ADC. Researchers can request modifications to the antibody, linker, or cytotoxic payload to suit specific experimental needs. This flexibility allows for the development of tailored solutions that align with the objectives of the research.

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Anti-Rat IgG(H+L)-C-PBD ADC

Anti-Rat IgG(H+L)-C-PBD ADC (CAT#: ADC-AA-066)

This ADC product is comprised of an anti-rabbit IgG(H+L) specific polyclonal antibody conjugated via a cleavable linker to PBD (pyrrolobenzodiazepine).The antibody portion is a secondary antibody. PBD is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Overview
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system, which is a protein complex composed of four peptide chains-two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers. IgG is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses.

Overview
Anti-rabbit IgG(H+L) specific polyclonal antibody

Species Reactivity
Rabbit

Name
Cleavable linkers

Description
Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracel

Name
PBD (pyrrolobenzodiazepine)

Description
Derived from various actinomycetes that show strong anti-tumor or antibiotic activities. PBDs are sequence-dependent DNA alkylating compounds and are proven to be more powerful than systemic chemotherapeutic drugs. As DNA minor groove binding agents, PBDs selectively cross-link specific DNA segments, hindering cell division and eventually lead to cell death.

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

The Anti-Rat IgG(H+L)-C-PBD ADC from Creative Biolabs was highly effective in our DNA cross-linking studies. The PBD conjugation provided robust cytotoxicity, making it a powerful tool for our research.

Excellent

Using the Anti-Rat IgG(H+L)-C-PBD ADC, we observed precise DNA targeting with significant cytotoxic effects. This product greatly enhanced the efficacy of our antibody-drug conjugate experiments.

Excellent

This ADC product delivered consistent and potent results in our lab. The PBD's ability to bind and cross-link DNA was impressive, making this an essential component in our research.

Excellent

Creative Biolabs' Anti-Rat IgG(H+L)-C-PBD ADC provided exceptional specificity and cytotoxicity. The cleavable linker ensured effective delivery of PBD, which significantly advanced our studies

Excellent

The Anti-Rat IgG(H+L)-C-PBD ADC exceeded our expectations in terms of binding affinity and cytotoxicity. The product performed reliably, making it a valuable addition to our research arsenal.

Q: 1: What is the composition of the Anti-Rat IgG(H+L)-C-PBD ADC?
A: The Anti-Rat IgG(H+L)-C-PBD ADC is composed of an anti-rabbit IgG(H+L) specific polyclonal antibody conjugated via a cleavable linker to pyrrolobenzodiazepine (PBD). The antibody serves as a secondary antibody, and PBD is a cytotoxic small molecule that binds to the DNA minor groove, cross-linking specific sites to inhibit DNA replication.
Q: 2: How does PBD function in the Anti-Rat IgG(H+L)-C-PBD ADC?
A: PBD, or pyrrolobenzodiazepine, is the cytotoxic component in this ADC. It functions by binding to the minor groove of DNA and cross-linking specific sites, thereby preventing the replication of DNA and leading to cell death. This mechanism is critical for targeting and eliminating cells that are bound by the antibody.
Q: 3: What is the role of the anti-rabbit IgG(H+L) polyclonal antibody in this ADC?
A: The anti-rabbit IgG(H+L) polyclonal antibody in this ADC specifically targets rabbit IgG antibodies. It serves as a secondary antibody, enabling the delivery of the cytotoxic PBD to cells that are bound by the primary antibody. This specificity ensures that PBD is directed only to the targeted cells, enhancing the efficacy of the ADC.
Q: 4: What support services does Creative Biolabs offer for using this ADC product?
A: Creative Biolabs offers comprehensive support services, including technical consultation on experimental design, optimization of ADC concentration and incubation times, and troubleshooting. They also provide custom conjugation services if specific modifications to the ADC are required for particular research applications.
Q: 5: Can the Anti-Rat IgG(H+L)-C-PBD ADC be customized for specific research needs?
A: Yes, Creative Biolabs offers customization services for this ADC. Researchers can request modifications to the antibody, linker, or cytotoxic payload to suit specific experimental needs. This flexibility allows for the development of tailored solutions that align with the objectives of the research.

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ADC-AA-047	anti-Rat IgG(HL)Fab-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-046	anti-Rat IgG(HL)Fab-N-MMAF ADC	Noncleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-038	anti-RIgG(HL)Fab-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-034	anti-RIgG(HL)-N-MMAF ADC	Noncleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-045	anti-Rat IgG(HL)-N-MMAF ADC	Noncleavable linkers	MMAF (Monomethyl auristatin F)

CAT#	Product Name	Linker	Payload
ADC-AA-017	anti-HIgG(Fab)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-011	anti-HIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
WJY-0423-LS106	Protein A-Calicheamicin ADC	Cleavable linkers	Calicheamicin
WJY-0423-LS107	Protein A-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
ADC-AA-061	Anti-MIgG(Fc)-C-DX8951 ADC	Cleavable linkers	DX8952

CAT#	Product Name	Linker	Payload
ADC-AA-059	Anti-HIgG(Fc)-C-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
WJY-0423-LS107	Protein A-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
ADC-AA-058	Anti-MIgG(Fc)-C-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)

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