Anti-Robo4-SPDP-NCS ADC (ADC-W-583) 
This ADC product is comprised of an anti-ROBO4 monoclonal antibody conjugated via a SPDP linker to NCS. The NCS is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
ADC Target
- Name
- ROBO4
- Alternative Names
- ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;
- Target Entrez Gene ID
- 54538
- Target UniProt ID
- B4DYV8
- Overview
- ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.
ADC Antibody
- Overview
- Anti-ROBO4 Antibody
- Species Reactivity
- Human
ADC Linker
- Name
- SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)
- Description
- Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
ADC payload drug
- Name
- NCS
- Description
- Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
Online Inquiry
USA
Tel:
Fax:
Email:
Europe
Tel:
Email:
Germany
Tel:
Email:
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
Contact usUSA
Tel:
Fax:
Email:
Europe
Tel:
Email:
Germany
Tel:
Email: