Anti-RTN4 MAb (Clone 1)-iFluor® 532 Succinimidyl Ester (WJY0-LS12992)

This product is comprised of an Human Anti-RTN4 IgG4-kappa antibody (Clone 1) labeled with iFluor® 532 Succinimidyl Ester. iFluor® 532 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
RTN4

Alternative Names
RTN-X

Overview
Reticulon 4, also known as neurite outgrowth inhibitor or Nogo, is a protein encoded by the RTN4 gene in humans and has been identified as a neurite outgrowth inhibitor unique to the central nervous system . During nerve development, Nogo is mainly expressed by neurons and provides inhibitory signals for the migration and germination of CNS endothelial (tip) cells, thereby limiting the density of blood vessels. There are three isoforms: Nogo A, B and C. Nogo-A has two known inhibitory domains, including the N-terminal amino Nogo and Nogo-66, the latter constituting the molecular extracellular loop. Both Amino-Nogo and Nogo-66 are involved in the inhibition reaction, of which Amino-Nogo is a strong inhibitor of neurite outgrowth, and Nogo-66 is involved in the destruction of the growth cone.

Studies have shown that blocking Nogo-A during neuronal damage (from diseases such as multiple sclerosis) can help protect or restore damaged neurons. [9] The study of the mechanism of this protein provides great potential for the treatment of autoimmune-mediated demyelinating diseases and spinal cord injury regeneration. It has also been found that it is a key participant in this process, and physical exercise can enhance the learning and memory processes of the brain. also shows that Nogo-A has a negative regulatory effect on blood vessel growth and repair after ischemic stroke. In the experimental stroke mouse model, Nogo-A gene deletion and antibody-mediated blockage resulted in enhanced revascularization and functional recovery. In addition, anti-Nogo-A antibody treatment reduces vascular leakage, the main complication after stroke.

ANTIBODY

Overview
Human Anti-RTN4 IgG4-kappa antibody (Clone 1)

Species Reactivity
Human

DYE

Name
iFluor® 532 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
537/560

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

Related Products

Online Inquiry

Name:

*Phone:

*E-mail Address:

*Products or Services Interested:

Company/Institution

Project Description:

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA

Tel:
Fax:
Email:
Europe

Tel:
Email:
Germany

Tel:
Email: