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- Anti-SDC1 MAb (Clone 2)-iFluor® 460 Succinimidyl Ester
Anti-SDC1 MAb (Clone 2)-iFluor® 460 Succinimidyl Ester (CAT#: WJY0-LS8500)
This product is comprised of an Chimeric Anti-SDC1 IgG4-kappa antibody (Clone 2) labeled with iFluor® 460 Succinimidyl Ester. iFluor® 460 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- SDC1
- Alternative Names
- SDC1; CD138; SDC; SYND1; syndecan; syndecan 1
- Overview
- Syndecan 1 is a protein encoded by the SDC1 gene in humans. This protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the Syndecan proteoglycan family. Syndecan-1 protein plays the role of integral membrane protein, and participates in cell proliferation, cell migration and cell-matrix interaction through its extracellular matrix protein receptors. Syndecan-1 is a sponge of growth factors and chemokines, is mainly bound by heparan sulfate chains. Syndecans-mediated internalization of HIV-1 tat protein requires cell binding, cell signaling, cytoskeletal organization and Syndecan receptors.Altered syndecan-1 expression has been detected in several different tumor types. Syndecan 1 may be a marker of plasma cells.
- Overview
- Chimeric Anti-SDC1 IgG4-kappa antibody (Clone 2)
- Species Reactivity
- Human
- Name
- iFluor® 460 Succinimidyl Ester
- Color
- Green
- Excitation⁄Emission (nm)
- 468/493
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-2515 | Anti-SDC1 (Indatuximab )-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-2514 | Anti-SDC1 (Indatuximab )-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-320 | Anti-SDC1-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-2511 | Anti-SDC1 (Indatuximab )-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-321 | Anti-SDC1-SPP-DM1 ADC | SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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