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- Anti-KDR ScFv-As2O3-nanoparticles ADC
Anti-KDR ScFv-As2O3-nanoparticles ADC (CAT#: ADC-W-443)
This ADC product is comprised of an anti-KDR monoclonal antibody conjugated via a linker to As2O3-nanoparticles.
- Product Information
- ADC Target
- ADC Antibody
- ADC payload drug
- Antibody clone #
- anti-VEGFR2 ScFv
- Name
- KDR
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kina
- Target Entrez Gene ID
- 3791
- Target UniProt ID
- A0A024RD88
- Overview
- Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
- Overview
- Anti-KDR Antibody ScFv
- Clone #
- anti-VEGFR2 ScFv
- Species Reactivity
- Human
- Name
- As2O3-nanoparticles
- Description
- Arsenic trioxide is an inorganic compound with the formula As
2O
3. This commercially important oxide of arsenic is the main precursor to other arsenic compounds, including organoarsenic compounds. Approximately 50,000 tonnes are produced annually.[4] Many applications are controversial given the high toxicity of arsenic compounds.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-584 | Anti-KDR-SPDP-NCS ADC | SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate) | NCS |
| ADC-W-1516 | Anti-KDR (Ramucirumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1517 | Anti-KDR (Ramucirumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1524 | Anti-KDR (Alacizumab pegol)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1525 | Anti-KDR (Alacizumab pegol)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
For Research Use Only. NOT FOR CLINICAL USE.
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