Bimagrumab-iFluor 405 (ADC-FL-002)

This product is comprised of an anti-ACVR2B monoclonal antibody (Bimagrumab) labeled with iFluor 405. iFluor 405 is a blue-fluorescent dye and it's excitation/emission is 401/421 nm.

TARGET

Name
ACVR2B

Alternative Names
ACVR2B; activin A receptor, type IIB; activin receptor type-2B; ActR IIB; HTX4; ACTRIIB; ActR-IIB;

Overview
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

ANTIBODY

Overview
Human Anti-ACVR2B IgG1-lambda antibody, Bimagrumab

Generic name
Bimagrumab

Species Reactivity
Human

DYE

Name
iFluor 405

Color
Blue

Excitation⁄Emission (nm)
401/421

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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